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and webcast to be held at 4:30 p.m. ET. NEW HAVEN, Conn., March 11, 2025 /PRNewswire/ --Trevi Therapeutics, Inc., a clinical-stage biopharmaceutical company developing the investigational therapy Haduvio  for the treatment of chronic cough in patients with idiopathic pulmonary fibrosis  and refractory chronic cough , today announced that senior management will host a conference call and live audio webcast on Tuesday, March 18, 2025, at 4:30 p.m. ET, to provide a corporate update and review the Company's financial results for the quarter and year ended December 31, 2024.Refractory chronic cough has no approved therapies in the U.S. and is defined as a persistent cough lasting >8weeks despite treatment for an underlying condition  and includes unexplained chronic cough. RCC affects ~2-3 million patients in the U.S. and is caused by cough reflex hypersensitivity in both the central and peripheral nerves. It is a highly debilitating disease and accompanied by a wide range o","market":"us","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":{"source":"yahoofinance","url":"https://finance.yahoo.com/news/trevi-therapeutics-report-fourth-quarter-200500840.html","rn_cache_url":null,"customStyle":"img, svg { display: none !important; }","selectors":"article","filters":"","directOrigin":true},"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://finance.yahoo.com/news/trevi-therapeutics-report-fourth-quarter-200500840.html","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"0","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":"yahoofinance","symbols":["BK4007","RCC","TRVI","LENZ","BK4139"],"gpt_icon":0},{"id":"2518187726","title":"TRVI Stock Soars on Meeting Primary Goal in Chronic Cough Study","url":"https://stock-news.laohu8.com/highlight/detail?id=2518187726","media":"Zacks","labels":["dataReport"],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2518187726?lang=en_us&edition=fundamental","pubTime":"2025-03-11 21:56","pubTimestamp":1741701360,"startTime":"0","endTime":"0","summary":"Shares of Trevi Therapeutics TRVI surged 41% yesterday after it reported positive top-line data from the phase IIa RIVER study evaluating its investigational therapy Haduvio as a potential treatment for refractory chronic cough .The study met its primary endpoint — treatment with Haduvio achieved a statistically significant reduction in the 24-hour cough frequency by 67% from baseline and 57% on a placebo-adjusted basis. Similar efficacy was also seen in Haduvio-treated patients when categorized across severity levels, with a 66% reduction in 24-hour cough frequency in patients with severe cough  and a 68% reduction in those with moderate cough . These results reinforce the drug’s potential as a broad treatment option, effectively reducing cough frequency regardless of baseline severity.Haduvio also demonstrated a strong treatment response, with 84% of patients achieving at least a 30% reduction in 24-hour cough frequency from baseline compared with 29% in the placebo group.Haduvio’s 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trial of Haduvio  for the treatment of patients with refractory chronic cough .Haduvio met the primary endpoint with a statistically significant reduction in the objective 24-hour cough frequency of 67% from baseline and 57% on a placebo-adjusted basis.Haduvio demonstrated a statistically significant reduction in 24-hour cough frequency of 66% in the severe cough  subgroup and 68% in the moderate cough  subgroup.84% of Haduvio patients had at least a 30% reduction in 24-hour cough frequency vs. baseline, as compared to 29% of placebo patients, a difference of 55%.Also Read: Why Is Cough-Focused Trevi Therapeutics Stock Skyrocketing On Thursday?A statistically significant reduction in 24-hour cough frequency, as measured by an objective cough monitor, was seen as early as Day7  for patients onHaduvio.Patients on Haduvio experienced a statistically significant improvement in patient-reported outcomes 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It has nearly tripled in value over the past three months.The New Haven, Conn., biopharmaceutical company shared positive topline results from a Phase 2a trial of Haduvio for the treatment of patients with refractory chronic cough. Haduvio met the primary endpoint by reducing cough frequency by 57% when adjusted for placebo results, which was statistically significant, Trevi said.Haduvio was effective for trial participants with both severe and moderate coughs.The results expand Haduvio's base of clinical support to a second chronic cough setting, Oppenheimer analyst Leland Gershell said in a note. 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